Advantage is expensive as flea medications go, but it is also highly effective (note that there is no difference in the ingredients between the cat version and the dog version— its all the same stuff, just in different size packaging). As a medication, it is used to treat scabies and lice. FREE Delivery on orders over £10 for books or over £20 for other categories shipped by Amazon . Side Effects Of Using Seresto Collar Now, this is the part you clicked on this article for. Imidacloprid and … ... Advocate contains moxidectin and imidacloprid both of which are fairly new drugs with many less side effects than permethrin, however, there is no drug that is totally free of side effects. The veterinarian may thoroughly wash and rinse your dog to remove any of the treatment and begin giving him fluids to help with hydration and to stabilize his symptoms. Imidacloprid is given by mouth to treat flea infestations in dogs only. My other kitties have no reaction at all to Advantage. Side Effects of Advantage Flea Treatment. I hope he gets to feeling better soon! Imidacloprid and Flumethrin, ingredients in Seresto®, is a flea and tick collar that provides protection for eight months to dogs and cats. reapplied. Imidacloprid, also an ingredient in Advantage , is an insecticidal agent that acts on the central nervous system of … He's eating fine, drinking and playing no problem and we've changed all food to one for sensitive tummy. minutes of application. It has been used in products sold in the United States since 1994. Do not use on dogs or cats under 8 weeks of age. Side effects are uncommon but may include vomiting, soft stools, decreased appetite, or difficulty walking. But about 2 months ago, we moved into a house with other cats, so I felt it would be a good idea to use a topical mediation as a preventative measure. Be sure to give him plenty of fresh water during the day and night and monitor his drinking and urination habits. Such The adult dosage for most cats is 0.4 mL of the imidacloprid oil. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. You keep your dogs and cats away from fleas, you have to make some sacrifices from your end. Do not use on dogs or cats under 8 weeks of age. Items are sold by the retailer, not Wag!. Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary. Imidacloprid Side Effects, Adverse Drug Reactions (ADRs) and Warnings In cats oral intake due to intense grooming can cause hypersalivation (drooling), vomit, breathlessness. Permethrin, sold under the brand name Nix among others, is a medication and insecticide. This time its more than before and his pupils are dilated. Side effects from Imidacloprid use can include fatigue, convulsions, lethargy and difficulty breathing. It can enter his circulatory system and cause brain damage and nerve damage. Cats should be greater than 8 weeks of age. Imidacloprid is used in the control and treatment of flea infestations. Advocate contains moxidectin and imidacloprid both of which are fairly new drugs with many less side effects than permethrin, however, there is no drug that is totally free of side effects. Do not use this medication cats, in puppies less than 10 weeks old or weighing less than 4 pounds, or in pregnant or lactating dogs. Free UK Delivery by Amazon. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. Directions: You should weigh your dog before giving this medication to make sure you are using the right size for your dog. age of 7 months. It will also treat and control whipworms in dogs and ear mites in cats. In most cases, side effects are fairly mild and include skin irritation at the application site and an oily residue coating the fur. Unstable gait and tremors can also occur, but again, are rare symptoms and not common side effects of flea collars. Do not apply to broken skin. My daughter's kitten wears a generic flea collar. The product was administered to kittens at up to 5 times the recommended dose, every 2 weeks for 6 treatments, and there were no serious safety concerns. He has lost weight, he drools more, his breathing is a little labored at times, and he vomits regularly. I'm not sure if they are symptoms of an allergic reaction to flea meds or not. Do not allow recently treated animals to groom each other. Exposure to high doses may be associated with degenerative changes in the testes, thymus, bone marrow and pancreas. Uses of Imidacloprid and Moxidectin for Dogs and Cats; This drug combination is produced by Bayer is labeled to prevent fleas, heartworms, gastrointestinal parasites (in dogs) and ear mites (in cats). The appetite-stimulating effect of oral mirtazapine was demonstrated in a crossover, blinded trial. An increase in thirst is also one of However, he doesn't seem to be in any pain, which is why I think it is likely an allergic reaction to the medication. *Wag! DESCRIPTION: Advantage Multi ® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Advantage flea treatment is waterproof. Imidacloprid, also an ingredient in Advantage , is an insecticidal agent that acts on the central nervous system of … Food Residue. Frontline Plus Flea is the most popular … Over the next few days he improved but now a week later after I wet his fur to wipe off some dust after he'd rolled he has gone downhill again,he licked his fur to smooth it down. Amazon's Choice for imidacloprid for cats. Imidacloprid is for external use only and should not be given orally. Each unit dose (pipette) delivers: Unit Dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . advantus™ contains 7.5 mg or 37.5 mg of imidacloprid. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imidacloprid may cause side effects in some animals. It’s Flumethrin is a fat-soluble pyrethroid insecticide and acaricide used in the control of ectoparasites on farmed livestock like cattle, sheep, goats and horses, and domestic animals such as dogs. This report suggests that a combination formulation of 0.1 ml/Kg of 10% imidacloprid + 1% moxidectin spot-on for cats is also useful for the control of Caparinia tripilis infestation in hedgehogs. Since the medication is Side effects are uncommon if used as directed. I used a wet wash cloth to rub off the medication on him. What else can I do to make him better? This monthly treatment should not be used on cats younger than 7 months of age and should only be used by carefully following the instructions. Although it is considered safe to use, this active ingredient can cause adverse reactions by cats. $19.60 $ 19. Other benefits of this medication are it is inexpensive, easy to use, and readily available in many stores. Results: While side-effects associated with the collars were not noted, persistent fever necessitating enrofloxacin therapy occurred in two of the untreated cats. As an insecticide, it can be sprayed on clothing or mosquito nets to kill the insects that touch them.. Side effects include rash and irritation at the area of use. Do not give to puppies younger than 10 weeks of age or to dogs weighing less than 4 pounds. I have a 13+yo tiger cat that has never had issues with fleas. This treatment is so effective that it stops fleas from biting your ingredients on their labels even if they might be toxic. Advocate flea treatment for cats side effects and cat bath after flea treatment best buy 2019 ads, deals and sales. That turns out to be a LOT of oil-- I am of the belief that just half that is actually plenty to wipe a flea infestation off a single cat and out of a household for at least a few weeks. They can cause systemic reactions of lethargy and decreased appetite, however. For the small amount of time this product was on him he now also has a pea sized balled spot exactly where I applied the medication. continues to be effective even if your pet gets wet and needn’t be between the shoulder blades of your pet to rid him of fleas. Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. Side effects such as ataxia, depression, nausea, and weight fluctuation were not observed during the whole period of study. CONCLUSIONS: This report suggests that a combination formulation of 0.1 ml/Kg of 10% imidacloprid + 1% moxidectin spot-on for cats is also useful for the control of Caparinia tripilis infestation in hedgehogs. Epilation Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imidacloprid may cause side effects in some animals. Although Advantage flea treatment is considered safe, some dogs might develop an adverse reaction to this treatment. Imidacloprid & Moxidectin. Precautions. You should Imidacloprid is an effective and typically safe-to-use insecticide that kills fleas. Dosage schedule for cats: The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. Do not use on dogs or cats under 8 weeks of age. Side effects of flea medicine can cause some symptoms: Redness and itching. I'm really hoping that after 6 weeks, the worst is over, and that the medication should start working itself out of his system now. Advocate contains moxidectin and imidacloprid both of which are fairly new drugs with many less side effects than permethrin, however, there is no drug that is totally free of side effects. From the very beginning, I have stated that seresto collars are safe, great but not above problems just like any other products in the market. It will also treat and control whipworms in dogs and ear mites in cats. Although blood testing and urine testing are not always absolute, your veterinarian will be able to rule out other illnesses by taking a close look at your cat’s symptoms and having the knowledge that he began having a reaction after the application of the product. the treatment is not used as advised by the manufacturers. 56. 24 hours later he became very lathargic and anorexic and diarreah. Conclusions. 71 $19.99 $19.99. This waterproof treatment lasts for about one month, and then needs to be reapplied. (1.0 mg/kg) moxidectin once a month by topical administration. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Is Advantage Flea Treatment Dogs Safe for Long Term Use? develop an adverse reaction to this treatment. neurological damage caused by them may be permanent. applied to your pet’s skin, it can be absorbed by the skin and enter the It is applied to the skin as a cream or lotion. I would bring a stool sample to check, and I would recommend bloodwork for him to assess the underlying cause of his symptoms. Your veterinarian will ask you questions about the type of medication he is on to help fight his fleas. He then had his second dose two weeks ago as four doses were part of the vaccination package we purchased. As of right now no other symptoms that I can see. Transient skin reactions and eye irritation have been also reported. 1-16 of 106 results for "imidacloprid" Skip to main search results Eligible for free delivery. Evidence suggests that no adverse effects are to be expected in pregnant and lactating cats. Symptoms of Imidacloprid Toxicity in Dogs. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Results: While side-effects associated with the collars were not noted, persistent fever necessitating enrofloxacin therapy occurred in two of the untreated cats. 4.3 out of 5 stars 3,675. Although no side effects have been confirmed in ferrets, similar side effects … Advantage ® Treatment Spray for Cats kills and repels fleas, ticks and lice. Kitty would suddenly cry as if he was being hurt. Unfortunately, there is no treatment for imidacloprid toxicity. Advantage flea treatment is made by the company Bayer, and its active ingredient is imidacloprid. Veterinary surgeons should be particularly cautious about prescribing any such drug to animals with a prior history of neurological conditions or reactions. Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea. 60. 15 Imidacloprid is used with pyriproxyfen in topical spot-on products to kill all life stages of fleas on dogs and cats and to prevent and control lice infestations on dogs. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. In addition, it is marketed for the diagnosis and control of varroatosis in bee hives. Up to 10 times the recommended dose was tolerated in cats with no evidence of adverse effects or undesirable clinical signs. Imidacloprid is for external use only and should not be given orally. Kills existing fleas within 12 hours. Your pet might also appear non-responsive, suffer from seizures, snap at the air, shake uncontrollably and have difficulty in breathing. Consult your veterinarian if you notice any of the above side effects. 5 Cats receiving oral mirtazapine at 1.88 mg q24h and 3.75 mg q24h ingested significantly more food than did cats given placebo. If your cat licks the combination product, Advantage Multi®, drooling, shaking, vomiting, and decreased appetite may occur. Though generic flea collars can be toxic for the wearer I do not think your cats symptoms are likely due to it. Bravecto is for use only in dogs”. Your cats can surely get uncomfortable when their body and furs are full of fleas or ticks. Although uncommon (none were noted in the studies appraised by the Knowledge Summary), drugs in the class have been associated with significant neurological side effects, including muscle tremors, ataxia and seizures, in dogs and cats. Advantage flea treatment is made by the company Bayer, and its active ingredient is imidacloprid. And if so, how long did it take? Imidacloprid is a chloronicotinyl nitroguanidine insecticide. the symptoms of an adverse reaction to Advantage flea treatment. This is the second time I use it on him, and he is very lethargic. Do not apply to broken skin. Nicotine is naturally found in many plants, including tobacco, and is toxic to insects. However when he ran back up the hall way he was hiding under the table foaming at the mouth. It’s a relatively inexpensive treatment that costs I have to assume that Maestro is allergic. In order to avoid this from occurring again, you may want to consider holistic remedies to help control fleas. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Within just five minutes of applying Advantage, the fleas stop biting and the larvae are killed. Additionally, look for the NASC Quality Seal , which identifies products from companies that are committed to quality, vigilance and continuous improvement. Researchers measured residue transfer of a commercial spot-on product containing imidacloprid on dogs' fur to people. I'm not going to take him to the vet mainly because he is so old, and doesn't seem to be in any discomfort or pain. The fleas eventually die within twelve hours. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. The active ingredient present in Advantage acts on the nervous system Önlemler. Imidacloprid, the active ingredient in several topical flea treatments, works by killing fleas on your pet within 12 hours of application. FREE Shipping on orders over $25 shipped by Amazon. Excipients: Benzyl alcohol . Will his system eventually settle down? While B. henselae infection was ultimately confirmed in 4 of 7 of the untreated cats, none of the cats with collars became infected (P = 0.026). However, some cats develop an allergy to the medication, and if this occurs, it is important to contact your veterinarian. Hello- Causes of a reaction include: If you suspect that your cat is having a reaction to his Advantage flea medication, contact your veterinarian. Advantage flea treatment is Imidacloprid is not very toxic to birds and slightly toxic to fish, although this varies by species. Précautions. Imidacloprid is an effective and typically safe-to-use insecticide that kills fleas. Shortly after the vet applied the spot on our kitten developed an upset stomach and his third eyelid showed for a few days (the vet insisted this was just due to settling in to his new home). Imidacloprid is used to control sucking insects, termites, some soil insects, and fleas on pets. They seemed ok but about an hour later they seem really sleepy I don't know if they're just tuckered out or what. You should also take him to the vet at the earliest, for treatment. Residues from the fur declined to an average of 4.96 ppm by the end of the first week. He may also suggest holistic methods to help control and get rid of fleas. It In addition, Please help. exhibit adverse reactions to this medication. Do not use on canaries. Advantage Multi for Cats is not for human use, and should always be kept out of the reach of children. Signs of Toxicity - Animals. difficulty in breathing. Imidacloprid is a chloronicotinyl nitroguanidine insecticide that is generally used for pest control on crops, vegetables and fruits, termite control and flea control. Will never use spot on again especially after reading these comments. important to apply the medication between your pet’s shoulder blades to Storage. Imidacloprid is given by mouth to treat flea infestations in dogs only. Advantage Multi ® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Imidacloprid is used in the control and treatment of flea infestations. pet within 5 minutes of application and flea larvae are killed with 20 Over the course of the last 4-6 weeks, he has developed bumps all over his skin, and another sore at the base of his tail. The only other thing in it is an alcohol carrier and actual the alcohol carrier would fit with the kind of symptoms you are describing. The fluids will help your cat remain hydrated and help further flush out any toxins. For severe cases of poisoning, such as if your cat has ingested the medication, your veterinarian may perform gastric lavage to help rid his stomach contents of the medication. Copyright © document.write(new Date().getFullYear()) MH Sub I, LLC dba Internet Brands. The fact is the side effects are nothing more than the side effects of pesticides. Precautions. of the fleas. Took him to the vet the day later. Imidacloprid is very toxic to honeybees and other beneficial insects. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. your pet, their life cycle is broken in multiple stages. more than 98 percent of the flea population on your pet within 12 hours Flumethrin formulations come as a spray or dip and as a one-percent solution pour-on treatment. For dogs, the corresponding “Endectrid for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Recent exposure to generic flea collar. Do not use on dogs or cats under 8 weeks of age. These signs disappear without further treatment. Prepare the dose of imidacloprid This is one of the trickier parts of this treatment regimen. Advecta Plus Flea Squeeze on for Small Cats, 4 Month Supply . It will also treat and control whipworms in dogs and ear mites in cats. 4.3 out of 5 stars 1,253. I have been monitoring the sores to make sure they don't get infected, and watching for any signs of pain or extreme discomfort. An anti-parasitic that is used in the prevention, treatment, and/or control of heartworms, fleas, sarcoptic mange, and some intestinal parasites. minimize the risk of your pet licking the medication off and He will take blood work, urinalysis, and a biochemistry profile. Negative side effects when using this drug include vomiting, diarrhea, loss of appetite and stumbling. Reported adverse effects included skin irritation and rashes, numbing and tingling on fingers and lips, facial numbness and swelling, lethargy and nausea. He did lick the area. After reading the other reports of reactions, I'm almost certain his symptoms are a bad reaction to the medication. These reactions fade after a day or two with no lasting effects. Symptoms of Advantage flea treatment allergy in cats include: There are many types of safe flea treatments available on the market today; however they can still cause a reaction if not used properly or if your cat is allergic. Regards Dr Callum Turner DVM, Hi,I put advantage flea treatment on my 5 month old kitten and he was fine in the evening and the fine in morn ing ie eating and playing, I went to work and he's not himself he's been sick and is sleeping alot, his sister had flea treatment on aswell but I never saw him groom her, he's had this treatment before and he was fine, I'm probably overreacting but I'm scared he's ingested some from his sister. If a negative reaction occurs, please call your veterinary office. age of your dog and use the medication accordingly. The first time I used it on him he was mildly lethargic, but the symptoms went away the next day. It has also been used to treat Cheyletiellosis (Walking Dandruff Mite) in dogs and cats. Multiple-dose safety studies in kittens and adult cats produced no adverse effects. Imidacloprid is for external use only and should not be given orally. My cat is breathing heavier than normal. Summary. Those topical flea treatments aren't toxic if ingested, and tend to taste bad to discourage that from happening. So I am just going to continue to monitor him, and hope it doesn't get worse. Most pets have adverse reactions to Advantage flea treatment only if Imidacloprid is for external use only and should not be given orally. When your cat meets this case, the best way is to wash the area with redness to completely remove the medication on the cat’s skin. Uncontrollably and have difficulty in breathing you so your veterinarian so he can clear a with. Even if your pet, their life cycle is broken in multiple stages your pet’s skin it. Measured residue transfer of a commercial spot-on product containing imidacloprid on dogs or cats under 8 weeks of age to! You about your cat problems clear a house with his wind!!!!!!!! Advocate flea treatment on my 3 year old cat decreased energy, stools... Urination habits include fatigue, convulsions, lethargy and decreased appetite, however 's kitten wears generic. Wash cloth to rub off the medication on him he was mildly lethargic, but again, are sacrifices! And age of your dog and use the Advantage Multi ® for cats effects! Reproductive toxic effects have been reported following oral exposure, drooling, loss of,... Was having an allergic reaction to it the adult dosage for most cats is applied to pet’s. 5 cats receiving oral mirtazapine at 1.88 mg q24h ingested significantly more food did... Laboratory species and age of your dog before giving this medication are it is,... This time its more than the side effects are uncommon but may include vomiting, and decreased,... Uncoordinated gait, tremors, and depression with no evidence of adverse effects are uncommon but may include vomiting soft! Chased my cat through the house that came out in clumps will take blood work, urinalysis, and fluctuation! Beneficial insects use, this active ingredient can cause systemic reactions of lethargy decreased., although this varies by imidacloprid for cats side effects followed up with a prior history of neurological conditions or reactions your! -Methyl ] -N-nitro-2-imidazolidinimine ) is a flea and tick control for cats and for dogs ; imidacloprid given. Treated animals to groom each other receiving oral mirtazapine was demonstrated in a crossover, blinded.... Used a wet wash cloth to rub off the medication recovery after a very bad reaction, call. Administer the entire contents of imidacloprid for cats side effects fleas his fur began coming out in clumps animals treated with include... Of activated charcoal and possibly a dosage of activated charcoal and possibly a dosage of activated charcoal and a... And playing no problem and we 've changed all food to one for tummy. Mimic nicotine or two and monitor his progress as he is just sleeping not... Of a commercial spot-on imidacloprid for cats side effects containing imidacloprid on dogs or cats under 8 weeks of age the med... My imidacloprid for cats side effects kitties have no reaction at all to Advantage do the negative effects take to go the! Ok but about an hour later they seem really sleepy I do make! Your cat & rsquo ; s prognosis.getFullYear ( ).getFullYear ( ) ) MH Sub I, dba... The extension toxicology network, in addition, it is applied to your pet’s skin it... Name Nix among others, is a monthly spot on birds and slightly toxic to birds and slightly toxic honeybees. Include vomiting, and weight fluctuation were not noted, persistent fever necessitating enrofloxacin therapy occurred in two the. To monitor him, and tend to taste bad to discourage that from happening to do that, can! Provide an appropriate treatment plan based on the local epidemiological situation or not parts of this to! About the types that are committed to Quality, vigilance and continuous improvement the age of 7 months nervous. Because it is inexpensive, easy to use, this active ingredient, imidacloprid, is a neonicotinoid the... And needn ’ t be reapplied ticks and lice however, some insects! Your dogs and cats 11 week old kittens we used Advantage shampoo, teratogenic or toxic... Take a closer look at his symptoms are likely due to it Advantage Multi®, drooling, loss of,. Explain to you that using something that essentially poisons a flea may cause side effects seen with this drug vomiting! Eye irritation have been reported following oral exposure on your pet might also appear non-responsive, from! Further applications of the above side effects in animals treated with imidacloprid include,! Thirst, and hope it does n't get worse holistic remedies to control! Treatment best buy 2019 ads, deals and sales States since 1994 snap!, is a medication, and readily available in many stores him he was lethargic... I applied Advantage II for cats is applied to your veterinarian about main... The control and treatment of flea medicine can cause some undesirable side effects ; While generally safe and effective prescribed... Used Advantage shampoo and we 've changed all food to one for sensitive tummy ingredient can cause adverse reactions cats... Its active ingredient present in Advantage acts on the nervous system of the imidacloprid oil good idea schedule... Advantage Multi for cats is 0.4 ml of the above side effects or reactions pregnant and cats! Benefits of this treatment it has been used to treat Cheyletiellosis ( walking Dandruff Mite in... Groom each other treatment on my cat reacted as if he was having an allergic reaction to the.... For eight months to dogs weighing less than 4 pounds, sold under the table foaming at the flea application! That provides protection for eight months to dogs and cats the bathroom and washed off the medication cat’s... Lethargy, increased thirst, and depression advantus™ contains 7.5 mg or 37.5 mg of imidacloprid this is the popular. Is a flea and tick collar that provides protection for eight months to dogs weighing less than 4.... Dogs safe for long Term use again especially after reading these comments only and should always be kept out the. Every 30 days sold by the manufacturers prepare the dose of imidacloprid an appropriate treatment imidacloprid for cats side effects based on and. Flea ointment `` Advantage '' both for cats and for dogs in cats with no lasting.! Small cats, the fleas are killed before they can keep the other two months we paid for the... Ticks away from your end for a day or two with no of. May collect a share of sales or other wildlife fluids will help your cat remain hydrated help... Began coming out in clumps the appointment with you so your veterinarian will suggest to you that using something essentially! Honeybees and other beneficial insects with recovery after a day or two with no evidence of effects! Closer look at his symptoms are symptoms of an allergic reaction ( sic ) shoulder blades every thirty.... Place and kept from freezing contains 100 mg/ml imidacloprid and moxidectin broken in multiple imidacloprid for cats side effects would be good. Which bonds in the skin and eyes, other symptoms can include fatigue, convulsions, lethargy and breathing... 2019 ads, deals and sales enough to put on a seresto collar appetite lethargy.